H?gh d???? can r??ult ?n v?r? h?gh bl??d ?r???ur? ?r b?d? t?m??r?tur?. Eff??t? b?g?n in just seconds to minutes of u?? and l??t b?tw??n f?v? and n?n?t? m?nut??. R????t?d ?????n? use ??n ?r?du?? ?dd??t??n ?nd other ?dv?r?? h??lth effects. In 2014, ????rd?ng to th? NSDUH, ?b?ut 913,000 Am?r???n? m?